Gene expression in major depressive disorder
نویسندگان
چکیده
منابع مشابه
Altered choroid plexus gene expression in major depressive disorder
Given the emergent interest in biomarkers for mood disorders, we assessed gene expression in the choroid plexus (CP), the region that produces cerebrospinal fluid (CSF), in individuals with major depressive disorder (MDD). Genes that are expressed in the CP can be secreted into the CSF and may be potential biomarker candidates. Given that we have previously shown that fibroblast growth factor f...
متن کاملSheehan’s Syndrome Presenting as Major Depressive Disorder
Sheehan’s syndrome or Simmond’s disease is a rare endocrine disorder seen in clinical practice. The clinical spectrum is diverse and a high index of suspicion together with a good clinical acumen and proper diagnostic approach helps in early diagnosis and prompt treatment of this endocrinopathy. Sheehan’s syndrome presenting as a major depressive disorder finds less mention in the literature.Th...
متن کاملMajor depressive disorder.
Copyright © 2008 Massachusetts Medical Society. Depression is related to the normal emotions of sadness and bereavement, but it does not remit when the external cause of these emotions dissipates, and it is disproportionate to their cause. Classic severe states of depression often have no external precipitating cause. It is difficult, however, to draw clear distinctions between depressions with...
متن کاملGene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder.
BACKGROUND Norepinephrine and glutamate are among several neurotransmitters implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also been demonstrated in people with MDD, and glia are critical modulators of central glutamatergic transmission. We studied glia in men with MDD in the region of the brain (locus coeruleus; LC) where noradrenergic neuronal cell bod...
متن کاملCircadian patterns of gene expression in the human brain and disruption in major depressive disorder.
A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human brain were difficult to characterize....
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2015
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2015.57